Acetyl Tetrapeptide-5 Liquid
Product Name: Acetyl Tetrapeptide-5 Liquid (Eyeseryl, Anti-Puffiness & Dark Circle Eye Care Peptide)
INCI Name: ACETYL TETRAPEPTIDE-5
Alias: Eyeseryl, Acetyl Tetrapeptide 5, Eye Silk Peptide, Anti-Bag Peptide, Anti-Dark Circle Peptide, Anti-Edema Active Peptide, Ocular Microcirculation Booster, Eye Contour Firming Peptide, Liquid Peptide Solution, Eye Care Specialized Active Ingredient
CAS No.: 820959-17-9
Appearance: Colorless to pale yellow transparent liquid, clear and uniform texture, no suspended impurities, no precipitation or turbidity.
Grade: Cosmetic Premium Grade
Source: This product is a synthetic tetrapeptide produced through advanced solid-phase peptide synthesis (SPPS) technology, followed by purification, sterilization, and standardization into a ready-to-use aqueous solution.
MOQ (Minimum Order Quantity): 1KG
Solubility: Fully soluble in water, glycerin, propylene glycol, butylene glycol, and various cosmetic aqueous systems.
Storage Condition: Sealed and stored in a cool, dry place away from direct sunlight. Recommended storage temperature 2–8°C for long-term preservation of peptide activity. Avoid repeated freeze-thaw cycles and high-temperature exposure. Keep tightly sealed after opening to prevent contamination and oxidation, ensuring stable peptide activity and efficacy.
Shelf Life: 24 Months (unopened, stored at 2–8°C)
Application: Widely used in eye serums, eye creams, eye gels, under-eye patches, eye contour treatments, anti-dark circle products, anti-puffiness formulations, eye area firming products, multi-effect eye care products, and various cosmetic formulations targeting eye contour concerns.
Acetyl Tetrapeptide-5, Eyeseryl, Anti-Puffiness Peptide, Dark Circle Remover, Eye Care Active Ingredient, Cosmetic Grade Peptide, Anti-Edema Peptide, Eye Bag Reduction, Ocular Microcirculation Booster, Liquid Peptide Solution, Under Eye Treatment, Eye Con
Acetyl Tetrapeptide-5 Liquid（CAS 820959-17-9）
Acetyl Tetrapeptide-5 (Eyeseryl) is a high-purity synthetic tetrapeptide specifically developed for delicate eye-area care, with dual core advantages of anti-puffiness and dark circle correction.
Different from traditional eye care ingredients that only provide surface-level moisturization, it targets the root causes of under-eye concerns: fluid retention and poor microcirculation.
Through its unique peptide structure, it inhibits angiotensin-converting enzyme (ACE) activity, enhances lymphatic drainage function, accelerates the elimination of excess fluid in the periorbital area, and rapidly reduces eye bags and morning puffiness.
Meanwhile, it improves ocular blood microcirculation, strengthens capillary walls, reduces vascular permeability, and effectively diminishes dark circles caused by blood stasis and poor circulation.
In addition, it stimulates fibroblast activity in the delicate eye contour skin, promotes collagen and elastin synthesis, improves skin firmness and elasticity, and helps smooth fine lines around the eyes.
With its ready-to-use liquid form, excellent water solubility, and proven clinical efficacy, it has become the gold-standard active ingredient for high-end eye care formulations.
Key Benefits
Powerful Anti-Puffiness, Rapid Eye Bag Reduction: Professional cosmetic-grade peptide active formula, inhibits ACE enzyme activity, enhances lymphatic drainage, effectively reduces fluid accumulation in the under-eye area. Significantly improves eye bag puffiness, delivers visible de-puffing results, and restores a refreshed eye contour appearance.
Dark Circle Correction, Brightens Eye Area: Improves ocular microcirculation, strengthens capillary walls, reduces vascular permeability, effectively diminishes dark circles caused by poor blood circulation. Brightens the under-eye area, evens skin tone, and restores radiant, well-rested eyes.
Collagen Boosting, Firms Eye Contour: Stimulates fibroblast activity, promotes collagen and elastin synthesis in delicate periorbital skin. Improves skin firmness and elasticity, reduces sagging, and helps smooth fine lines and wrinkles around the eyes.
Anti-Edema Mechanism, Scientifically Proven: Unique ACE-inhibiting peptide mechanism, scientifically validated anti-edema efficacy. Targets the root cause of puffiness rather than just masking symptoms, delivering long-lasting eye contour improvement.
Ultra-Gentle Eye-Safe Formula: High-purity peptide with no harmful impurities, specially formulated for the delicate eye area. Non-irritating, non-sensitizing, and ophthalmologist-tested safe for use around the eyes. Suitable for all skin types including sensitive skin.
Ready-to-Use Liquid, Easy Formulation: Standardized 0.1% aqueous solution, ready to use without additional dissolution. Excellent water solubility allows easy incorporation into serums, gels, creams, and masks. Simplifies production process and ensures consistent peptide activity.
Excellent Stability, Long-Lasting Activity: Optimized formulation with stabilizers, maintains peptide activity under conventional cosmetic processing and storage conditions. Resistant to oxidation and degradation, ensuring consistent efficacy throughout the product shelf life.
Broad Formula Compatibility: Highly compatible with other cosmetic ingredients including hyaluronic acid, caffeine, vitamin C, retinol, niacinamide, plant extracts, and other peptides. Synergistic effects when combined with complementary eye care actives.
Applications
Eye Serums & Essences Series: Core active ingredient for anti-puffiness eye serums, dark circle correction essences, multi-effect eye contour serums, and under-eye rejuvenation treatments. Targets eye bags, dark circles, and fine lines for comprehensive eye care.
Eye Creams & Eye Gels Series: Key active for firming eye creams, de-puffing eye gels, hydrating eye balms, and anti-aging eye creams. Improves eye contour texture, reduces puffiness, and brightens the under-eye area.
Under-Eye Patches & Masks Series: Professional active for hydrogel eye patches, bio-cellulose eye masks, under-eye sheet masks, and collagen eye patches. Delivers intensive anti-puffiness and brightening benefits in mask format.
Eye Contour Treatments Series: Specialized active for eye contour lifting treatments, periorbital rejuvenation products, eye area firming lotions, and targeted dark circle correctors. Provides professional-grade eye contour care.
Multi-Effect All-In-One Eye Care: Core peptide for all-in-one eye care products combining anti-puffiness, dark circle reduction, anti-aging, and moisturizing benefits. Simplifies skincare routines with comprehensive eye solutions.
Men's Eye Care Products: Key active for men's anti-dark circle eye creams, de-puffing eye gels, and energizing eye treatments. Addresses puffiness and dark circles common in men's skincare concerns.
Clinical & Professional Eye Care: Professional-grade active for clinic eye treatments, post-procedure eye care, and dermatologist-recommended eye products. Delivers visible, clinically proven results.
Certificate Of Analysis (COA)
Test Item | Specification | Result |
Product Name | Acetyl Tetrapeptide-5 Solution | Complies |
INCI Name | ACETYL TETRAPEPTIDE-5 | Complies |
CAS Number | 820959-17-9 | Complies |
Grade | Cosmetic Grade | Complies |
Appearance | Colorless to pale yellow transparent liquid | Complies |
Odor | Characteristic, slight | Complies |
Active Peptide Content | 0.1% ± 0.02% | 0.10% |
Purity (HPLC) | ≥95.0% (peptide basis) | 98.2% |
Molecular Formula | C₂₀H₂₈N₈O₇ | Complies |
Molecular Weight | 492.48 g/mol | Complies |
pH Value | 5.0 – 7.0 | 5.8 |
Relative Density | 1.00 – 1.05 g/cm³ | 1.02 g/cm³ |
Refractive Index | 1.330 – 1.345 | 1.338 |
Water Content | ≥98% | 98.5% |
Solubility in Water | Freely soluble | Complies |
Heavy Metals | ≤10 ppm | <5 ppm |
Arsenic (As) | ≤1 ppm | <0.5 ppm |
Lead (Pb) | ≤2 ppm | <0.5 ppm |
Mercury (Hg) | ≤1 ppm | <0.1 ppm |
Cadmium (Cd) | ≤1 ppm | <0.1 ppm |
Total Plate Count | ≤100 CFU/g | <10 CFU/g |
Yeast & Mold | ≤10 CFU/g | <10 CFU/g |
E. coli | Negative | Negative |
S. aureus | Negative | Negative |
P. aeruginosa | Negative | Negative |
Source | Synthetic (Solid-Phase Peptide Synthesis) | Complies |
Vegan | 100% Vegan, cruelty-free | Complies |
Storage | 2–8°C, sealed, protected from light | Complies |
Frequently Asked Questions (FAQ)
Q1: What is the MOQ of Acetyl Tetrapeptide-5 liquid?
A1: The standard MOQ is 1KG. We support sample orders for formula testing, efficacy evaluation, and trial production. We also offer customized concentrations and specifications for mass production requirements.
Q2: What are the core functions of Acetyl Tetrapeptide-5 in eye care cosmetics?
A2: It has three core functions: powerful anti-puffiness and eye bag reduction through ACE inhibition and lymphatic drainage enhancement; dark circle correction by improving ocular microcirculation and strengthening capillaries; and eye contour firming by promoting collagen and elastin synthesis. It is a rare multi-functional eye-care peptide active ingredient.
Q3: What is the recommended dosage in cosmetic formulas?
A3: Eye serums and essences: 2%–5%; Eye creams and lotions: 1%–3%; Eye gels and masks: 2%–4%; Under-eye patches: 3%–5%. The exact dosage can be adjusted according to product positioning, target efficacy, and formulation requirements.
Q4: Is Acetyl Tetrapeptide-5 safe for the delicate eye area?
A4: Yes. The product is highly purified with no harmful impurities, specially formulated for the delicate periorbital area. It is non-irritating, non-sensitizing, and has been ophthalmologist-tested for eye-area safety. It is suitable for sensitive skin and all skin types of eye care formulations.
Q5: What is the advantage compared with other eye care ingredients like caffeine?
A5: Caffeine primarily works through vasoconstriction and provides temporary de-puffing effects. Acetyl Tetrapeptide-5 works through multiple mechanisms: ACE inhibition for lymphatic drainage, microcirculation improvement for dark circles, and collagen stimulation for firming. It provides longer-lasting, more comprehensive eye contour improvement with both immediate and cumulative benefits.
Q6: What are the formula usage notes?
A6: Water-phase addition, add at temperatures below 40°C to preserve peptide activity; compatible with most water-soluble cosmetic ingredients including hyaluronic acid, niacinamide, and other peptides; avoid high-temperature processing (>60°C) and strong oxidizing agents; adjust pH to 5.0–7.0 for optimal stability; sealed cold storage (2–8°C) recommended for bulk inventory.
Q7: Can it be combined with other eye care actives? What are the best combinations?
A7: Yes, it synergizes beautifully with many eye care ingredients. Top combinations include: Acetyl Tetrapeptide-5 + Caffeine (double de-puffing power); + Vitamin K (dark circle correction synergy); + Hyaluronic Acid (hydration + firming); + Retinol (anti-aging + de-puffing); + Niacinamide (brightening + barrier); + Dipeptide-2 (lymphatic drainage synergy). Our technical team can provide customized formulation guidance for optimal synergistic effects.
Q8: Can you provide stable supply and professional technical support?
A8: We strictly control core indicators such as peptide purity, concentration, activity, and pH to ensure consistent batch-to-batch stability. We support long-term bulk order supply, and provide one-stop professional services including formulation development, efficacy testing guidance, stability testing protocols, and after-sales technical support.
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